Influence of Raloxifene and 17β-oestradiol on Rats’ Oral Mucosal Structure
نویسندگان
چکیده
The aim of this study was to determine histological changes in rats’ oral mucosa at induced postmenopausal oestrogen decrease and after administration of raloxifene and 17β-oestradiol. Wistar female rats were ovariectomized and divided into experimental groups; basal – after ovariectomy without drugs BOV, taking raloxifene RA and oestradiol – OVH (10 rats per group). Additionally, 10 rats without ovariectomy and drug supplementation made up control group – CL. Specimens of oral buccal mucosa were stained with haematoxylin and eosin. While the oral mucosa in BOV group had a slight epithelium atrophy, mucosa in rats taking raloxifene did not differ much from that in control group without ovariectomy. Oral mucosa in group taking oestradiol did not differ significantly from that in the group without ovariectomy except characteristic changes in reproductive layer of mucosa epithelium. Lack of oestrogen in experimental menopause caused changes in oral mucosa i.e. shortening of epithelial ridge. These changes were inhibited in different degree after administration of raloxifene and oestradiol.
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